This autumn vegetarian lasagna is filled with ricotta and mozzarella cheeses, roasted butternut squash, and Brussels sprouts! It’s a unique take on lasagna that would be perfect for a vegetarian Thanksgiving or Christmas dinner. 
A slice of pesto Roasted Butternut Squash and Brussels sprouts lasagna with ricotta. A beautiful autumn vegetarian lasagna that would be perfect as a vegetarian Thanksgiving main dish.  

There are two types of people: those who love Brussels sprouts, and those who loathe them. It was only recently I realized the reason for their bad rap. I’ve always halved, tossed in olive oil, and roasted my B-sprouts. I picked up a frozen bag while at Whole Foods one day, mistakenly thinking they would come in handy on a busy night down the road.

The night came where I pulled that bag out of the freezer and cooked them in a saute pan. Ick! Where did my crisp, golden-skinned, tender, buttery Brussels sprouts go? And what were these flavorless mush balls? Moral of the story: if you’ve never roasted these babies, make a point of trying it this week, mmkay? 

A collage of how to make an autumn vegetarian lasagna with Brussels sprouts and butternut squash.

See, they’re cute! 

My Spring Veggie and Goat Cheese Lasagna got rave reviews from my friends (thanks friends!) for being so quick and simple. And delicious. And filled with veggies that any kid would eat. So I decided to use the same method with winter vegetables.

The thing I love most is that it lasts two days in our house and is even better on the second day after the flavors have had a chance to meld. 

4 year old response to this recipe: “I want to have this baaa-zanya every night for dinner!”

Yield: 6

Brussels Sprout and Butternut Squash Vegetarian Lasagna

Prep Time 15 minutes
Cook Time 40 minutes
Total Time 55 minutes

This autumn vegetarian lasagna is filled with ricotta and mozzarella cheeses, roasted butternut squash, and Brussels sprouts! It's a unique take on lasagna that would be perfect for a vegetarian Thanksgiving or Christmas dinner.ย 

Brussels Sprout and Butternut Squash Vegetarian Lasagna

Ingredients

  • 3 cups quartered Brussels sprouts
  • 3 cups diced butternut squash
  • 1 Tablespoon butter
  • 1 shallot, chopped
  • 6 fresh sage leaves, chopped
  • 1 egg
  • 15 oz ricotta cheese
  • 1/2 cup grated Parmesan cheese, plus 1/4 cup for topping
  • 1/2 teaspoon freshly grated nutmeg
  • 7 oz fresh pesto sauce (I used Trader Joe's)
  • 8 oz fresh mozzarella cheese, drained of water and sliced
  • lasagna noodles (Fresh lasagna sheets or cooked. "No boil" does not work well in this recipe)

Instructions

  1. Preheat oven to 400 degrees F. Place Brussels sprouts and butternut squash on a large rimed baking sheet. Drizzle with extra virgin olive oil and toss to coat. Sprinkle with a pinch of salt and pepper. Roast until lightly browned in parts and tender, about 15 minutes.
  2. Melt butter in a saute pan over medium heat. Cook shallots and sage until tender. Add to Brussels sprouts and squash, tossing to combine.
  3. In a medium bowl, stir together egg, ricotta, Parmesan, and nutmeg.
  4. Spread a thin layer of pesto over bottom of a 11 x 7 inch baking dish. Cover with one layer of noodles. Spoon half the vegetable mixture over pasta. Spread half the ricotta mixture over the vegetables. Cover with 1/2 the mozzarella slices. Top with a second layer of lasagna noodles and spread pesto over. Top with remaining vegetables, ricotta, third layer of noodles, and pesto. Top with remaining mozzarella slices and 1/4 cup Parmesan. Bake at 350 degrees F for 40 minutes or until bubbly.
Nutrition Information:
Yield: 8 Serving Size: 1
Amount Per Serving: Calories: 402 Total Fat: 28g Saturated Fat: 11g Trans Fat: 0g Unsaturated Fat: 15g Cholesterol: 75mg Sodium: 463mg Carbohydrates: 21g Net Carbohydrates: 0g Fiber: 5g Sugar: 4g Sugar Alcohols: 0g Protein: 20g
Nutrition information is automatically calculated by Nutritionix. I am not a nutritionist and cannot guarantee accuracy. If your health depends on nutrition information, please calculate again with your favorite calculator.